Juvederm® XC | Juvederm® Ultra Plus XC | Juvederm® VOLUMA™

Juvederm® is composed of cross-linked hyaluronic acid, a natural
substance found in the body. Hyaluronic acid plays a key role in the maintenance
of skin volume and hydration, eye volume and shape, as well as joint lubrication
and cushioning.

Hyaluronic acid retains water — absorbing more than 1,000 times its weight — and
adds volume to the skin’s surface. In addition, hyaluronic acid binds with collagen
and elastin, transporting essential nutrients to these fibers.
Juvederm Information

The triple combination of collagen, elastin and hyaluronic acid provides structure,
elasticity and volume to the skin and contributes to its overall appearance. The
hyaluronic acid in Juvederm® is called non-animal stabilized hyaluronic
acid (NASHA) because it is not derived from animal sources.

Juvederm® comes pre-mixed with lidocaine for additional comfort during your injection. Juvederm®
is manufactured using HYLACROSSTM
technology, creating a smooth gel with enduring support.

For decades, hyaluronic acid has been utilized by medical practitioners in numerous
therapeutic procedures. In 2003, the U.S. Food and Drug Administration (FDA) approved
the first hyaluronic acid dermal filler for the correction of facial wrinkles and
folds, such as nasolabial folds (the folds running from the sides of the bottom
of the nose to the outer corners of the mouth). Juvederm® comes in
three formulations:

Juvederm® Ultra

Juvederm® Ultra (also known as Juvederm®) is a next-generation,
cross-linked hyaluronic acid dermal filler approved by the FDA in June 2006 for
treatment of nasolabial folds. Juvederm® Ultra adds volume to the
face and smoothes
Juvederm Ultra Treatment

moderate to severe facial wrinkles and folds. With advanced injection techniques,
Juvederm® can also be used to lift and contour facial features.

Cross-linking refers to a process in which the individual chains of hyaluronic acid
are bound or ‘cross-linked’ together, transforming the liquid hyaluronic acid into
a soft gel. The firmness of the gel depends on the degree of cross-linking of the
individual hyaluronic acid chains. The body metabolizes cross-linked hyaluronic
acid more slowly, resulting in a longer duration of effect.

As an advanced, cross-linked hyaluronic acid, the results of a Juvederm®
treatment will typically last up to a year or more. Results will vary depending
upon injector technique, the facial area in which it is applied, and upon the individual’s
muscle movement, skin and health characteristics. For example, in areas of the face
where there is less exaggerated muscle movement, Juvederm® will often
last longer. Regular BOTOX® treatments in conjunction with Juvederm®
may help extend the duration of Juvederm®. Juvederm®
is typically used to correct finer lines or for less bulking than Juvederm®
Ultra Plus.

Juvederm® Ultra Plus

Juvederm® Ultra Plus (also called Juvederm® Plus)
has more cross-linked molecules per ml than Juvederm®, and therefore
is used to treat deeper wrinkles and folds. Healthcare professionals also use
Juvederm Ultra Plus

Juvederm® Ultra Plus in some liquid
face lift procedures
where more bulking or more defined sculpting is desirable.
It provides more volume than Juvederm® Ultra and some other dermal

The most common side effects of Juvederm® Ultra and Juvederm®
Ultra Plus include temporary redness, swelling, bumps and bruising. Consult your
medical practitioner for complete details and potential side effects.

Juvederm® VOLUMA

In October of 2013, the FDA approved the first and only Hyaluronic Acid filler, Juvederm® VOLUMA injectable gel, to instantly add
volume to the cheek area. Hyaluronic Acid (HA) is a naturally occurring,
hydrating substance found in your skin. As you age, you start to lose HA, which causes the skin to lose structure and volume. VOLUMA works to restore contour and a more youthful appearance by providing a subtle lift, for up to two years in patients over 21 years of age.
VOLUMA is different than any other Juvederm® injectable gel filler product, in that VOLUMA is formulated to add volume to the cheek area, whereas other products target moderate to severe wrinkles and folds around the nose and mouth areas.

Juvederm Ultra Treatment

Juvederm® VOLUMA lasts longer than other HA dermal fillers, lasting up to two years! This means fewer injections and less overall downtime.

After 24 hours of treatment with VOLUMA, you should be able to resume your normal activities. Side effects are moderate and generally last
2 to 4 weeks. Common side effects include temporary reactions at the treatment site such as tenderness, swelling, firmness, lumps/bumps, bruising, pain, redness, discoloration, and itching.

Your health care professional may use Juvederm® in combination
with other dermal fillers and botulinum toxins to create a liquid face lift or non
surgical facial rejuvenation.

A medical practitioner who is more experienced with Juvederm® can
often help achieve better, more pleasing and enduring results, which means you are
getting more for your money. We have determined a number of medical practitioners
nationally who have extensive experience or training with dermal filler medical
procedures. To see a list of experienced healthcare professionals in your area,
or to receive a special discount on your procedure.


Contributing Medical Practitioner:
W. Grant Stevens MD FACS, Marina Del Rey, CA ~ Jules A. Feledy Jr. MD, Chevy Chase, MD
Wm. Stephen Martin M.D., Mobile, AL ~ Deason Dunagan M.D., Huntsville, AL
J Charlie Finn MD, Chapel Hill, NC ~ Paul M. Friedman MD, Houston, TX
Lisa M. Donofrio MD, Madison, CT ~ Lydia Parker M.D., Beachwood, OH
Anna Pare MD, Atlanta, GA